7 Pharmacology and Pharmacokineticsīupropion inhibits the reuptake of norepinephrine and dopamine, and unlike many other antidepressants, it has little effect on serotonin reuptake. 7 Bupropion, specifically, was involved in 11,222 reported exposures, and moderate or major outcomes were reported in 1,453 exposures and death in 4 cases where bupropion was the only substance. In 2014, antidepressants were the fifth most common substance class involved in human poison exposures reported to US poison control centers. While these measures improved the safety at therapeutic doses, seizures continue to be a serious effect in overdoses.Īs with other antidepressants, bupropion is commonly involved in poisonings. Bupropion was reintroduced to the market 3 years later with label adjustments that included a lower maximum daily dose and contraindications for use in epilepsy, eating disorders, or head trauma. ![]() 6 Data showed that seizure risk was dose-dependent and highest in patients with eating disorders, previous head trauma, or epilepsy. ![]() The most significant side effect of bupropion is its risk of seizures.īupropion has been associated with seizures even at therapeutic doses and was removed from the market shortly after it was initially approved in 1986. Although often lumped with serotonergic SSRI antidepressants, it has limited serotonergic properties. 5 Unlike tricyclic antidepressants, bupropion is a monocyclic aminoketone and in a pharmaceutical class by itself. Bupropion is a unique antidepressant with FDA-approved indications for major depressive disorder 1-32, seasonal affective disorder 1,2, smoking cessation 4, and as an adjunct to diet and exercise for chronic weight management in adult patients with BMI >=30 kg/m2 when co-formulated with naltrexone.
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